CML PB Plasma/ PBMCs (Chronic Phase)Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a myeloproliferative disease with an incidence of 1 2 cases per 100,000 adults. On the molecular level, CML is caused by the formation of Philadelphia chromosome, a genetic translocation t(9; 22)(q34; q11. 2) which creates a fusion oncogene of BCR ABL. The expression of Tyrosine kinase BCR ABL1 in hematopoietic stem progenitor cells transforms them into leukemic cells,

PMID 17557898

NK cells provide rapid responses to viral-infected cells

CD14+CD16- monocytes are classical monocytes that are primarily involved in phagocytosis and cytokine secretion

accounting for about 80-90% of all monocytes in the blood

NC2101392 (Fresh

Monocytes and their macrophage and dendritic cell progeny serve three main functions

when unstained

Naïve T cells differentiated in bone marrow

Merzaban JS

Recent evidence suggests that basophils are an important source of the cytokine

Mediators released by platelets can impact how white blood cells and endothelial cells respond to inflammatory stimuli

PMID 18987355